Cholesterol and triglyceride fatty acid synthesis in apolipoprotein E2-associated hyperlipidemia.
نویسندگان
چکیده
منابع مشابه
Cholesterol and triglyceride fatty acid synthesis in apolipoprotein E2-associated hyperlipidemia.
To investigate whether increased endogenous lipogenesis contributes to elevated plasma lipid levels in individuals with apolipoprotein (apo) E2-associated hyperlipidemia (E2-HL), plasma pool cholesterol and triglyceride fatty acid syntheses were measured in subjects with E2-HL and in those with normal lipid levels. Subjects were given a priming dose of deuterium oxide (D2O) followed by maintena...
متن کاملRegulation of cholesterol and fatty acid synthesis.
In mammals, intracellular levels of cholesterol and fatty acids are controlled through a feedback regulatory system mediated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs). SREBPs are synthesized as inactive precursors bound to membranes of the endoplasmic reticulum. When cells are deprived of cholesterol and fatty acids, NH(2)-terminal fragments...
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We reported previously that dietary cholesterol produces hypertriglyceridemia in the rat, accompanied by reduced oxidation and increased incorporation of exogenous fatty acid into hepatic triglyceride and increased secretion of very low density lipoprotein. We now report that dietary cholesterol also increases net hepatic fatty acid synthesis and the incorporation of newly synthesized fatty aci...
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From the ‡Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel, the §Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4935, the ¶Schwartz Center for Metabolism and Nutrition, MetroHealth Center, Cleveland, Ohio 44109, and the Department of Molecular Biology, Princeton University, Princeton, New Jersey...
متن کاملClinical and Population Studies Familial Combined Hyperlipidemia Is Associated With Alterations in the Cholesterol Synthesis Pathway
Objectives—Familial combined hyperlipidemia (FCH) is a common familial lipid disorder characterized by increases in plasma total cholesterol, triglyceride, and apolipoprotein B-100 levels. In light of prior metabolic and genetic research, our purpose was to ascertain whether FCH cases had significant abnormalities of plasma markers of cholesterol synthesis and absorption as compared to unaffect...
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ژورنال
عنوان ژورنال: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
سال: 1992
ISSN: 1049-8834
DOI: 10.1161/01.atv.12.1.106